contribution of the nucleus cuneiformis to the antinociceptive effects of systemic morphine on inflammatory pain in rats

نویسندگان

abdolaziz ronaghi

mohammad ebrahimzadeh

abbas haghparast

چکیده

introduction: the role of midbrain reticular formation, which includes the nucleus cuneiformis (ncf), as a crucial antinociceptive region in descending pain modulation has long been investigated. in this study, we tried to highlight the role of ncf in morphine-induced antinociception in formalin-induced pain model in rats. methods: a total of 201 male wistar rats weighing 260-310 g were used in this study. the effective dose of morphine in systemic administration (intraperitoneal i.p.) was determined after a dose- and time-response protocol. in consequent groups, bilateral electrolytic lesion (500 μa, 30 sec) or reversible inactivation (lidocaine 2%) were used in the ncf before systemic administration of morphine, and then, the nociceptive test was immediately carried out. results: the results showed that administration of 6 mg/kg morphine, 30 min before the formalin test, is the best dose- and time-response set in these experiments. the obtained data also indicated that bilateral electrical destruction or reversible inactivation of the ncf significantly decreased antinociceptive responses of systemic morphine (6 mg/kg i.p.) during the second phase of formalin test (p<0.05). discussion: therefore, it seems that opioid receptors located in the ncf may be involved in modulation of central sensitization which occurred in inflammatory pain in rats.

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Contribution of the Nucleus Cuneiformis to the Antinociceptive Effects of Systemic Morphine on Inflammatory Pain in Rats

Introduction: The role of midbrain reticular formation, which includes the nucleus cuneiformis (NCF), as a crucial antinociceptive region in descending pain modulation has long been investigated. In this study, we tried to highlight the role of NCF in morphine-induced antinociception in formalin-induced pain model in rats. Methods: A total of 201 male Wistar rats weighing 260-310 g were used in...

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Contribution of the Nucleus Cuneiformis to the Antinociceptive Effects of Systemic Morphine on Inflammatory Pain in Rats

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عنوان ژورنال:
basic and clinical neuroscience

جلد ۳، شماره ۱، صفحات ۳۵-۴۳

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